April 15th, 2016

Investment to help meet growing demand for rare disease treatments
Expected to create 400 jobs in Ireland at new state-of-the-art facility in Co. Meath

Dublin, Ireland – 15 April, 2016 – Shire plc (LSE: SHP, NASDAQ: SHPG) announces that it plans to expand its global biotechnology manufacturing capacity over the next four years by investing US$400 million in Ireland to meet the rapidly growing demand for its highly innovative products and robust pipeline.

Shire will create a new, state of the art biologics manufacturing campus, which it expects will lead to the creation of approximately 400 permanent jobs on a 120 acre site at Piercetown, County Meath. Construction of the new site will begin in mid-2016 with the site expected to be operational by mid-2019. 

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